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DR. BHUBANESWAR BOROOAH CANCER INSTITUTE

(Tata Memorial Centre)

Grant-in-Aid Institute of Department of Atomic Energy

GOVERNMENT OF INDIA

Departments

Home Departments DBT Centre For Molecular Biology & Cancer Research Research Activities

Research Activities

 

RESEARCH PUBLICATIONS

 

  1. Jorvekar SB, Jala A, Rai A, Jangili S, Adla D, Borkar G, Das A, Kakati K, Das K, Sarma A, Mutheneni SR. Urinary Metabolomics Identified Metabolic Perturbations Associated with Gutka, a Smokeless Form of Tobacco. Chemical research in toxicology. 2023 Apr 17;36(4):669-84.
  2. Sarma A, Kataki AC, Rai AK, Hazarika M, Roy PS, Kalita M, Deka M, Chattopadhyay I. Promoter Hypermethylation of ATG16L2, TFAP2A, EBF2, Calcitonin, ABL1 Kinase Domain T315I Mutation Association with Imatinib Therapy Resistance and Median Survival in CML Patients of North-East India. Asian Pacific Journal of Cancer Care. 2023 Feb 17;8(1):35-42.
  3. Das R, Kumar R, Rai AK, Sarma A, Kakoti L, Kataki AC, Bhattacharyya M, Kalita M. HPV and p16 expression association with 5-year survival in oral squamous cell carcinoma patients of North-East India. medRxiv. 2023:2023-01.
  4. Sarma P, Barmon D, Rai AK, Kataki AC, Sarma A, Kakoti L, Barman D, Kalita M. Tobacco chewing, Alcohol consumption, reuse of cloth sanitary pads is significant risk factors for High Risk HPV infection and PAP positivity among Rural Women of Kamrup District, North-East India. medRxiv. 2023:2023-01.
  5. Das S, Sarma A, Das BC, Sarma DJ, Barman R, Bhattacharyya M, Kataki AC, Rai AK. Analysis of Biochemical and Hematological Parameters During the First and Second Wave of SARS-CoV-2 Infection among North-East Indian Cancer Patients. Asian Pacific Journal of Cancer Care. 2022 Nov 10;7(4):637-42.
  6. Hazarika M, Reddy R, Rai AK, Roy PS, Iqbal A, Barbhuiyan S, Raj N, Mallik S, Sarangi SS. COVID-19 Prevalence and Survival Outcome in Pediatric Cancer Patients Undergoing Chemotherapy: A Study from Tertiary Cancer Center of North-East India. Asian Pacific Journal of Cancer Care. 2022 Aug 31;7(3):475-80.
  7. Joyeeta Talukdar, Tryambak Pratap Srivastava, Gayatri Gogoi, Avdhesh Rai, Ruby Dhar, and Subhradip Karmakar. Oncometabolite profiling identifying estrogen-responsive genes in breast cancer Journal of Clinical Oncology 2022 40:16_suppl, e13611-e13611
  8. Pal U, Manjegowda MC, Singh N, Saikia S, Philip BS, Kalita DJ, Rai AK, Sarma A, Raphael V, Modi D, Kataki AC. The G-protein-coupled estrogen receptor, a gene co-expressed with ERα in breast tumors, is regulated by estrogen-ERα signalling in ERα positive breast cancer cells. bioRxiv. 2022:2022-06.
  9. Roy P, Sarma A, Kataki AC, Rai AK, Chattopadhyay I. Salivary microbial dysbiosis may predict lung adenocarcinoma: A pilot study. Indian Journal of Pathology and Microbiology. 2022 Jan 1;65(1):123.
  10. Barman R, Taw MJ, Rai AK, Krishnatreya M, Sarma A, Das S, Bhattacharyya M, Kataki AC, Kalita M. Impact of reverse transcriptase real-time polymerase chain reaction-cycle threshold values on SARS-CoV-2–positive cancer patients undergoing treatment. Advances in Human Biology. 2021 Oct 1;11(Suppl 1):S90-4.
  11. Kumar R, Rai AK, Phukan MM, Hussain A, Borah D, Gogoi B, Chakraborty P, Buragohain AK. Accumulating Impact of Smoking and Co-morbidities on Severity and Mortality of COVID-19 Infection: A Systematic Review and Meta-analysis. Current Genomics. 2021 Dec 12;22(5):339.
  12. Shantanu PA, Syamprasad NP, Rajdev B, Gawali B, Rai AK, Rahman T, Naidu VM. Delineating the role of autophagy in driving the resistance to cancer chemotherapy. Annals of Oncology Research and Therapy. 2021 Jul 1;1(2):78.
  13. Deka KB, Sarma P, Sarma A, Das G, Karmakar S, Rath GK, Rai AK. Prevalence of Epstein–Barr virus in North-East Indian breast cancer patients' blood. Annals of Oncology Research and Therapy. 2021 Jul 1;1(2):111.
  14. Saikia S, Pal U, Kalita DJ, Rai AK, Sarma A, Kataki AC, Limaye AM. RUNX1T1, a potential prognostic marker in breast cancer, is co-ordinately expressed with ERa, and regulated by estrogen receptor signalling in breast cancer cells. Molecular Biology Reports. 2021 Jul;48:5399-409.
  15. Rai AK, Panda M, Das AK, Rahman T, Das R, Das K, Sarma A, Kataki AC, Chattopadhyay I. Dysbiosis of salivary microbiome and cytokines influence oral squamous cell carcinoma through inflammation. Archives of Microbiology. 2021 Jan;203:137-52.
  16. Panda M, Rai AK, Rahman T, Das A, Das R, Sarma A, Kataki AC, Chattopadhyay I. Alterations of salivary microbial community associated with oropharyngeal and hypopharyngeal squamous cell carcinoma patients. Archives of microbiology. 2020 May;202:785-805.
  17. Barmon D, Rai A, Kataki A. Study on epidemiology and screening of cervical cancer in ne india. International Journal of Gynecological Cancer. 2019 Sep 1;29(Suppl 3):A98-.
  18. Das AK, Baishya N, Sarma A, Kataki AC, Rai AK, Kalita CR. Assessment and clinicopathological correlation of matrix metalloproteinase 9 expression in nasopharyngeal carcinoma. Journal of Carcinogenesis. 2019;18.
  19. Singh V, Singh AP, Sharma I, Singh LC, Sharma J, Borthakar BB, Rai AK, Kataki AC, Kapur S, Saxena S. Epigenetic deregulations of Wnt/ß-catenin and transforming growth factor beta-Smad pathways in esophageal cancer: Outcome of DNA methylation. Journal of cancer research and therapeutics. 2019 Jan 1;15(1):192-203.
  20. Bhushan A, Singh A, Kapur S, Borthakar BB, Sharma J, Rai AK, Kataki AC, Saxena S. Identification and validation of fibroblast growth factor 12 gene as a novel potential biomarker in esophageal cancer using cancer genomic datasets. OMICS: A Journal of Integrative Biology. 2017 Oct 1;21(10):616-31.
  21. Singh V, Singh LC, Vasudevan M, Chattopadhyay I, Borthakar BB, Rai AK, Phukan RK, Sharma J, Mahanta J, Kataki AC, Kapur S. Esophageal cancer epigenomics and integrome analysis of genome-wide methylation and expression in high risk northeast Indian population. Omics: a journal of integrative biology. 2015 Nov 1;19(11):688-99.
  22. Kumar R, Rai AK, Das D, Das R, Kumar RS, Sarma A, Sharma S, Kataki AC, Ramteke A. Alcohol and tobacco increases risk of high risk HPV infection in head and neck cancer patients: Study from North-East Region of India. PloS one. 2015 Oct 16;10(10):e0140700.
  23. Singh V, Singh LC, Singh AP, Sharma J, Borthakur BB, Debnath A, Rai AK, Phukan RK, Mahanta J, Kataki AC, Kapur S. Status of epigenetic chromatin modification enzymes and esophageal squamous cell carcinoma risk in northeast Indian population. American Journal of Cancer Research. 2015;5(3):979.
  24. Sarma A, Hazarika M, Das D, Kumar Rai A, Sharma JD, Bhuyan C, Kataki AC. Expression of aberrant CD markers in acute leukemia: A study of 100 cases with immunophenotyping by multiparameter flowcytometry. Cancer Biomarkers. 2015 Jan 1;15(4):501-5.
  25. Deka P, Deka P, Rai A, Chandra AM, Sharma J, Barmon D, Baruah U. CD44 AS A PREDICTOR OF EPITHALIAL OVARIAN CANCER. InINTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER 2014 Nov 1 (Vol. 24, No. 9, pp. 421-421). 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA: LIPPINCOTT WILLIAMS & WILKINS.
  26. Rai AK, Das D, Kataki AC, Barmon D, Aggarwal D, Deka P, Shrivastava S, Sharma JD, Sarma A, Baruah U, Sharma M. Hybrid capture 2 assay based evaluation of high-risk HPV status in healthy women of north-east India. Asian Pacific Journal of Cancer Prevention. 2014;15(2):861-5.
  27. Das D, Rai AK, Kataki AC, Barmon D, Deka P, Sharma JD, Sarma A, Shrivastava S, Bhattacharyya M, Kalita AK, Sharma M. Nested multiplex PCR based detection of human papillomavirus in cervical carcinoma patients of North-East India. Asian Pacific Journal of Cancer Prevention. 2013;14(2):785-90.
  28. Rai AK, Freddy AJ, Banerjee A, Kurkalang S, Rangad GM, Islam M, Nongrum HB, Dkhar H, Chatterjee A. Distinct involvement of 9p21-24 and 13q14. 1-14.3 chromosomal regions in raw betel-nut induced esophageal cancers in the state of Meghalaya, India. Asian Pacific Journal of Cancer Prevention. 2012;13(6):2629-33.
  29. Rai AK, Freddy AJ, Chatterjee A. P3. 15. Raw betel-nut induced oral and esophageal cancers in Meghalaya. Oral Oncology Supplement. 2009;1(3):206.

 

BOOK CHAPTER

 

  1. Rai AK, Borah P, Kataki AC. Molecular Profiling of Gynaecological Cancer and Breast Cancer. InFundamentals in Gynaecologic Malignancy 2023 Jan 1 (pp. 9-24). Singapore: Springer Nature Singapore.
  2. Anupam Sarma, Shiraj Ahmed, Avdhesh Kumar Rai. Chapter: Hereditary Cancer: An Overview; Book: Principles and Practice of Oncology, 2021.
  3. Avdhesh Kumar Rai Anupam Sarma, Shiraj Ahmed,. Chapter: Cancer Cytogenetics; Book: Principles and Practice of Oncology, 2021

 

RESEARCH PROJECTS (ON-GOING)

 

  1. Project Title: Identification of predictive/diagnostic biomarkers for metastasis in Head and Neck Cancer Patients ( Principal Investigator: Dr A. K. Rai; Collaboration: Division of Biological Sciences, BARC, Mumbai: Duration 2021-2024)
  2. Evaluation of DNA damage response genes, protein(s) expression in Hypopharyngeal and laryngeal cancer patients of North-East India: Clinical relevance with radiotherapy outcomes ( Principal Investigator: Dr A. K. Rai; Funding Agency: ICMR, Govt of India: Duration 2022-2024)
  3. Evaluation of Truenat™ HPV-HR Chip-based Real Time Duplex PCR Test for High Risk Types 16, 31 and 18, 45 in Oropharyngeal Cancer Patients of North East India: A proof of concept study (Co- Principal Investigator: Dr A. K. Rai; Funding Agency: Bigtec Labs Pvt Ltd (Molbio Diagnostics), Bengaluru ; Duration 2021-2024)
  4. Assessment of Cancer Antigen CA15.3 as predictive and prognostic marker of tumor burden and recurrence in breast cancer patients of North-East India (Co- Principal Investigator: Dr A. K. Rai; Funding Agency: ICMR, Govt of India: Duration 2022-2024)
  5. Identify the DNA Adduct and associated metabolic alterations in upper aerodigestive Tract cancer with smokeless tobacco chewers in the North-East region of India: A Metabolomics Approach ( Co-Principal Investigator: Dr A. K. Rai; Collaboration: NIPER, Guwahati; Funding Agency: SERB, Govt of India Duration 2021-2024)
  6. Identification of Hereditary Breast and Ovarian Cancer (HBOC) syndrome families with breast cancer and their BRCA1 & BRCA2 gene mutation profiling in North East Indian population ( Co-Principal Investigator: Dr A. K. Rai; Collaboration: AIIMS, New Delhi; Funding Agency: NCDIR-ICMR, Govt of India Duration 2020-2023)
  7. To Establish a ready network of clinical trial units across the National Cancer Grid to promote multi-centric collaborative in the field of drug and device development ( Co- Investigator: Dr A. K. Rai; Collaboration: MultiCentre; Funding Agency: BIRAC-DBT, Govt of India Duration 2020-2023)
  8. The non-canonical estrogen receptor repertoire in breast cancer: towards refined disease classification and therapeutic decision ( Co-Principal Investigator: Dr A. K. Rai; Collaboration: IIT, Guwahati; Funding Agency: ICMR, Govt of India Duration 2020-2023)

 

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